About the Author The author received his Ph. His dissertation research, supervised by Dr. Paul Johnson, concerned the regulation of microcirculatory blood flow in skeletal muscle. Steven Mayer.
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About the Author The author received his Ph. His dissertation research, supervised by Dr. Paul Johnson, concerned the regulation of microcirculatory blood flow in skeletal muscle.
Steven Mayer. Klabunde studied the role of adenosine and other tissue metabolites on skeletal muscle blood flow regulation. In , he went to the Department of Physiology, West Virginia University College of Medicine as an Assistant Professor where he taught medical students and continued his work on mechanisms of local blood flow regulation in skeletal muscle. He left West Virginia in to become a Senior Cardiovascular Group Leader in the Department of Pharmacology at Abbott Laboratories where he conducted extensive in vivo and in vitro research on new drugs.
During that time, he also taught cardiovascular physiology and pharmacology at the University of Illinois College of Medicine at Rockford, and at the Chicago Medical School. In , Dr. From , Dr. Klabunde served as the Director of the Clinical Presentation Continuum Curriculum for the medical school. In , he was awarded the highest teaching award from the American Physiological Society — the Arthur C. Guyton Physiology Educator of the Year Award. In the fall of , Dr.
Cardiovascular Physiology Concepts
It starts by considering the early embryonic circulation, where blood passes through the valveless tube heart at a rate that surpasses the contractions of its walls, suggesting that the blood is not propelled by the heart, but possesses its own motive force, tightly coupled to the metabolic demands of the tissues. Rather than being an organ of propulsion, the heart, on the contrary, serves as a damming-up organ, generating pressure by rhythmically impeding the flow of blood. The validity of this model is then confirmed by comparing the key developmental stages of the cardiovascular system in the invertebrates, the insects and across the vertebrate taxa. The salient morphological and histological features of the myocardium are reviewed with particular reference to the vortex. The complex, energy-dissipating intracardiac flow-patterns likewise suggest that the heart functions as an organ of impedance, whose energy consumption closely matches the generated pressure, but not its throughput. Hyperdynamic states occurring in arteriovenous fistulas and congenital heart defects, where communication exists between the systemic and pulmonary circuits at the level of atria or the ventricles, demonstrate that, once the heart is unable to impede the flow of blood, reactive changes occur in the pulmonary and systemic circulations, leading to pulmonary hypertension and Eisenmenger syndrome.
Cardiovascular Physiology Concepts, 2nd Edition
About the Author